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It is identified after a premature birth has occurred at about 16–18 weeks into the pregnancy.

Those chemicals that are implicated in increasing the risk for miscarriage are DDT, lead, formaldehyde, arsenic, benzene and ethylene oxide.

Video display terminals and ultrasound have not been found to have an effect on the rates of miscarriage.

Chorionic villus sampling is a similar procedure with a sample of tissue removed rather than fluid.

These procedures are not associated with pregnancy loss during the second trimester but they are associated with miscarriages and birth defects in the first trimester.

A disruption in normal immune function can lead to the formation of antiphospholipid antibody syndrome.